Photoperiodic effects on hypothalamic β-endorphin and POMC mRNA
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چکیده
منابع مشابه
Effects of cannabinoids on neuropeptide Y and β-endorphin expression in the rat hypothalamic arcuate nucleus.
The control of appetite and satiety is extremely complex and involves a balance between neurotransmitters and neuropeptides to stimulate and/or inhibit feeding behaviour. The effect of cannabinoids on food intake is well established, but little is known about the mechanism of action underlying their activity. In the present report, the effect of pharmacological manipulation of the cannabinoid r...
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Many important fields of research had a humble origin. In the distant past, A J P Martin's discovery that amino acids could be separated by paper chromatography and Moore and Stein's use of columns for quantitative amino acid analysis provided the first steps towards the determination of structure in complex biologically active molecules. They opened the door to reveal the essential relationshi...
متن کاملHypothalamic NPY, AGRP, and POMC mRNA responses to leptin and refeeding in mice.
Food deprivation (FD) increases hypothalamic neuropeptide Y (NPY) and agouti-related protein (AGRP) mRNA levels and decreases proopiomelanocortin (POMC) mRNA levels; refeeding restores these levels. We determined the time course of changes in hypothalamic NPY, AGRP, and POMC mRNA levels on refeeding after 24 h FD in C57BL mice by in situ hybridization. After 24 h deprivation, mice were refed wi...
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We summarize here our new discovery that the endogenous opioid peptide β-endorphin (BEP), by virtue of reducing body stress and maintaining active immune system, as well as, balancing the levels of pro-inflammatory and anti-inflammatory cytokines, destroys tumor cells and stops them from being transformed into metastatic cancer cells.
متن کاملLoss of leptin receptors on hypothalamic POMC neurons alters synaptic
32 Adaptive changes in hypothalamic neural circuitry occur in response to alterations in 33 nutritional status. This plasticity at hypothalamic synapses contributes to the control of food 34 intake and body weight. Here we show that genetic ablation of leptin receptor gene 35 expression in POMC neurons (POMC: Lepr GFP) induces alterations at synapses on 36 POMC neurons in the arcuate nucleus of...
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ژورنال
عنوان ژورنال: Regulatory Peptides
سال: 1994
ISSN: 0167-0115
DOI: 10.1016/0167-0115(94)90460-x